Some time after the Mousekewitz's have settled in America, they find that they are still having problems with the threat of cats. That makes them eager to try another home out in the west, where they are promised that mice and cats live in peace. Unfortunately, the one making this claim is an oily con artist named Cat R. Waul who is intent on his own sinister plan. Unaware of this, the Mousekewitz's begin their journey west, while their true cat friend, Tiger, follows intent on following his girlfriend gone in the same direction.

美国鼠谭2:西部历险记是由西蒙·威尔斯执导，艾丽卡·约恩,列夫·梅勒,雪莉·琳恩,詹妮弗·达林,万娜·邦塔,拉里·莫斯主演的动漫片，在1991年上映播出，二七一十四影院提供了美国鼠谭2:西部历险记在线观看，并且还可以支持手机看，不需要下载播放器,方便广大影迷。